产品货号：
Z13939
中文名称：
CRKL抗体
英文名称：
Anti-CRKL Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CRKL Antibody |
| 指标别名 | CRK like proto-oncogene;adaptor protein;CRKL |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,FCM |
| 基因名称 | CRKL |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human CrkL(286-303aa FPFTHVKIFDPQNPDENE),different from the related mouse and rat sequences by one amino acid. |
| 实际分子量 | 39KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CRKL(v-crk sarcoma virus CT10 oncogene homolog(avian)-like) also called ONCOGENE°CRKL,encodes a 303-amino acid polypeptide with a predicted molecular mass of 36kD.While°CRKL is not the human homolog of CRK,it is similar to protein-tyrosine kinases with SH2 and SH3(src homology) domains.By fluorescence in situ hybridization,the°CRKL gene is localized to chromosome 22q11,centromeric of the chronic myelogenous leukemia breakpoint region.Senechal et al.(1996) showed that°CRKL becomes phosphorylated when overexpressed,activates Ras-dependent and JNK pathways,and transforms fibroblasts.The authors also found°CRKL to be a substrate for the BCR-ABL tyrosine kinase,leading them to conclude thatCRKL is a tyrosine kinase and an oncogene.Crkl was required for normal cellular responses to Fgf8,including survival and migration,Erk activation,and target gene expression. |
| Uniprot ID | P46109 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | v-crk sarcoma virus CT10 oncogene homolog(avian)-like |
| 蛋白名全称 | Crk-like protein |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Flow cytometry (FCM) 1～3μg/1×106 cells |
相关搜索：CRKL抗体，CRKL多抗，Anti-CRKL Antibody